Rampage 2 (2025) picks up after the events in Chicago, where primatologist Davis Okoye and his loyal friend, the genetically mutated gorilla George, saved the city from catastrophic destruction. Now, Davis and George live in relative peace, but a new threat begins to stir. A shadowy organization has acquired the technology behind the genetic mutations and plans to use it to create a new line of super-creatures, unleashing havoc on an even larger scale.
As mysterious attacks start occurring in cities around the globe, Davis is called back into action, joined by scientists and military forces who suspect a new wave of monstrous creatures is on the rise. This time, however, the mutations affect both animals and humans, creating terrifying hybrids with extreme strength, intelligence, and aggression. Davis and George face off against these mutated creatures, with George now considered a hero but also a prime target for those who want to control his power.
Throughout the journey, Davis unearths shocking secrets about the origins of these genetic experiments and the sinister motives of those driving the chaos. As George fights alongside Davis, their bond is tested like never before, facing insurmountable odds and pushing them to their physical and emotional limits.
Rampage 2 combines thrilling action with deeper emotional stakes, exploring themes of loyalty, friendship, and the consequences of scientific tampering with nature. With larger-than-life battles, improved CGI, and a global stage for its destruction, the film promises a high-octane, monster-filled adventure that challenges Davis and George to save the world once more.