The story follows BSAA operative Chris Redfield, who uncovers a deadly bioterrorist plot led by Glenn Arias, a former arms dealer turned vengeful bioterrorist. Arias intends to release a new strain of the virus, capable of turning people into zombies while keeping their cognitive functions intact. Chris recruits Leon S. Kennedy, a skilled government agent, and Rebecca Chambers, a biochemistry professor and former S.T.A.R.S. medic, to stop the impending threat.
Rebecca, researching a vaccine for the new virus strain, becomes a target when Arias attacks her lab. Though she manages to survive, Arias kidnaps her, planning to use her as a vessel for his dead wifeโs consciousness. Chris and Leon team up to rescue Rebecca while unraveling Arias’s twisted plan to unleash the virus on New York City as an act of vengeance for his destroyed wedding and personal losses.
The final act unfolds in Arias’s stronghold, where Chris and Leon face hordes of zombies and genetically engineered monsters. Rebecca, after escaping captivity, aids the team in stopping the spread of the virus. The confrontation culminates in a showdown between Chris and Arias, where Chris ultimately defeats him in a high-stakes battle filled with intense action.
With Arias dead and the virus neutralized, the team prevents a massive bioterror attack. Rebeccaโs vaccine proves successful, providing hope for future outbreaks. The movie ends with Chris, Leon, and Rebecca reflecting on their ongoing battle against bioterrorism, each resolved to continue their fight to protect humanity.